Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
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Interleukin-6 regulates anti-arthritic effect of methotrexate via reduction of SLC19A1 expression in a mouse arthritis model
INTRODUCTION Methotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that SLC19A1 is associated with the efficacy of MTX. We here examined the relationship between the efficacy of MTX and the expression of SLC19A1 in glucose 6-phosphate isomerase (GPI)-induced arthritis. We found that interleukin-6 (IL-6) regulated the expression of SLC19A1, so we studied the effect o...
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چکیده ندارد.
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متن کاملSilibinin Improves the Anti-arthritic Activity of Methotrexate in Zymosan-Induced Arthritis in Rats
Because of low toxic effects of plant-derived drugs, it has become a research focus in disease prevention and treatment, especially those chronic diseases requiring long-term treatment. The present study was designed to evaluate the effects of silibinin (SIL) when administered with methotrexate (MTX) in animal model of zymosaninduced arthritis in rats. Male Wistar rats are used for induction an...
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ژورنال
عنوان ژورنال: Arthritis Research & Therapy
سال: 2012
ISSN: 1478-6354
DOI: 10.1186/ar3821